Modeling a Neural Oscillator that Paces Heartbeat in the Medicinal Leech
نویسندگان
چکیده
منابع مشابه
Slow oscillations of membrane potential in interneurons that control heartbeat in the medicinal leech.
In the preceding paper (Arbas and Calabrese, 1987), we identified several properties that contribute to the activity of neurons (HN cells) that control heartbeat in the medicinal leech. Premotor HN (7) interneurons, which do not generate the heartbeat rhythm, exhibit Na+-dependent fast action potentials, Ca2+-mediated plateau potentials in the absence of Na+, and hyperpolarization-activated "re...
متن کاملIonic Conductances Underlying the Activity Control Heartbeat in the Medicinal Leech of Interneurons That
Electrical properties of interneurons that control heartbeat in the leech (HN cells) were studied using intracellular recording and stimulation in isolated ganglia bathed by salines of various ionic compositions. Substitution of Na+ ions in the bath by Tris stopped the spontaneous firing of HN cells and led to their gradual hyperpolarization by 15-20 mV. In the absence of Na+, HN neurons produc...
متن کاملGeneration and coordination of heartbeat timing oscillation in the medicinal leech. I. Oscillation in isolated ganglia.
1. The interactions among the four pairs of interneurons (HN(1)-HN(4)) of the heartbeat timing oscillator are confined to the third and fourth ganglia (G3 and G4). In isolation, G3 and G4 each produces a rhythm essentially the same as that shown when the two ganglia are linked together. 2. The local circuits in both ganglia have the same general form. In both the oscillation centers on a bilate...
متن کاملGeneration and coordination of heartbeat timing oscillation in the medicinal leech. II. Intersegmental coordination.
1. A network of four pairs of interneurons, HN(1)-HN(4), times the heartbeat of the medicinal leech. The following model accounts for the stable phase relationships in the network and the network's response to perturbation, entrainment, and stimulation. 2. There are two centers of oscillation, one the HN(3) pair in the third ganglion, the other the HN(4) pair in the fourth ganglion. 3. The two ...
متن کاملHeartbeat control in the medicinal leech: a model system for understanding the origin, coordination, and modulation of rhythmic motor patterns.
We have analyzed in detail the neuronal network that generates heartbeat in the leech. Reciprocally inhibitory pairs of heart interneurons form oscillators that pace the heartbeat rhythm. Other heart interneurons coordinate these oscillators. These coordinating interneurons, along with the oscillators interneurons, form an eight-cell timing oscillator network for heartbeat. Still other interneu...
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ژورنال
عنوان ژورنال: American Zoologist
سال: 1993
ISSN: 0003-1569
DOI: 10.1093/icb/33.1.16